propofol infusion syndrome mnemonic
All content, including text, graphics, images and information, contained on or available through this site/blog is for medical education only. Propofol-related Infusion Syndrome is an acute refractory bradycardia leading to asystole and one or more of: Metabolic acidosis (base deficit > 10 mmol.l(-1)) Rhabdomyolysis; ... JONES criteria mnemonic for diagnosis of rheumatic heart disease (RHD) Acute rheumatic fever 1. Diabetic Ketoacidosis (DKA), Alcohol ic ketoacidosis or starvation ketosis Paraldehyde, Phenformin (neither used in U.S. now) Propofol Infusion Syndrome has been proposed as a replacement in mnemonic Salicylate s (do not miss Chronic Salicylate Poisoning ) IV. This condition was originally described in children (73, 74) and led to warnings against propofol in pediatric intensive care . Propofol infusion syndrome is more likely to develop at doses greater than 4-6 mg/kg/h administered for >48 h. The information on this site/blog is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Propofol infusion syndrome Propofol is a short-acting intravenously administered anesthetic agent widely used in both adults and children for sedation or anesthesia [ 36 , 37 ]. A small subset of patients receiving propofol may develop a propofol infusion syndrome characterized by metabolic acidosis, cardiac dysfunction, rhabdomyolysis, and hypertriglyceridemia, often with a fatal outcome. Mortality from propofol infusion syndrome is independently associated with fever and hepatomegaly in children, and electrocardiogram changes, hypotension, hyperkalaemia, traumatic brain injury and a mean propofol infusion rate >5 mg/kg/h in adults. It is the triad of metabolic acidosis, skeletal myopathy and acute cardiomyopathy. Propofol infusion syndrome Hello friends! The propofol infusion syndrome is an adverse reaction characterized by bradycardia and cardiac failure potentially resulting in asystole in the setting of metabolic acidosis, rhabdomyolysis, and hyperkalemia. ... Mnemonics (868) Musculoskeletal system (21) NEET (19) Nephrology (65) Neurology (231) Neurosurgery (4) Nutrition (35) Obstetrics (110) Oncology (95) Ophthalmology (128) due to high intravenous doses of lorazepam, diazepam, nitroglycerine, esmolol, phenytoin) ... Any medication which could be causing acidosis should be stopped immediately (especially: propofol, … Propofol (propofol infusion syndrome) Propylene glycol intoxication (e.g. The main features of the syndrome consist of cardiac failure, rhabdomyolysis, severe metabolic acidosis and renal failure. Propofol infusion syndrome is a rare but extremely dangerous complication of propofol administration. Recently several cases have been reported in adults, too. Propofol infusion syndrome (PRIS) is a rare and often fatal syndrome described in critically ill children undergoing long-term propofol infusion at high doses. Propofol Infusion Syndrome has been proposed as a replacement in mnemonic; Iron, Isopropyl Alcohol, and Isoniazid (due to Seizures) Lactic Acidosis; Ethylene Glycol, Ethyl Alcohol; Rhabdomyolysis; Salicylates (do not miss Chronic Salicylate Poisoning) Other … Certain risk factors for the development of propofol infusion syndrome are described, such as appropriate propofol doses and durations of administration, carbohydrate depletion, severe illness, and concomitant administration of catecholamines and glucocorticosteroids. doses of >4mg/kg/hr for >48 hours associated with propofol infusion syndrome -> severe metabolic acidosis, bradycardia, multiorgan failure and treatment resistant cardiac arrest (described mainly in children) expensive (compared to midazolam and morphine)